SEDEX 100LT — The Benchmark LT‑ELSD for High‑Performance (U)HPLC and SFC

Ultimate LT‑ELSD Sensitivity for Advanced Chromatography Workflows

The SEDEX 100LT represents the highest tier of Low‑Temperature Evaporative Light‑Scattering Detection (LT‑ELSD), delivering unmatched sensitivity, robustness, and truly universal detection for HPLC, UHPLC and SFC applications.
It reveals analytes that UV, RI, or MS cannot detect without complex conditions, ionization steps, or chromophore requirements — making it a premier choice for high‑precision quantification and comprehensive sample profiling.

Built on SEDERE’s exclusive Low‑Temperature evaporation technology, the SEDEX 100LT detects virtually all compounds less volatile than the mobile phase, regardless of optical or electrochemical properties. Its advanced optical and electronic design ensures maximum performance while maintaining an attractive price‑to‑performance ratio.

Sensitivities Comparable or Superior to CAD — With Direct Optical Detection

Thanks to its optimized nebulization system and highly refined optical scattering detection, the SEDEX 100LT achieves sensitivity levels comparable — and in many applications superior — to Charged Aerosol Detectors (CAD).

While both ELSD and CAD rely on aerosol formation, their detection principles differ significantly:

• CAD uses an indirect detection mechanism, where dried particles undergo an ion‑transfer charging process before their signal is measured. This means the response can depend on ionization efficiency and may vary across chemical families.
• LT‑ELSD/DELD uses direct optical detection, measuring light scattered by particles immediately after nebulization and drying, without ion‑transfer steps. This direct optical approach is agnostic to ionization properties, and therefore potentially more universal in its response across diverse analyte classes (although this universality, while likely, is not formally proven).

This combination of refined nebulizer engineering, Gas‑Assisted Optical Focusing, and high‑stability photodiode detection provides superior baseline quality, strong S/N ratios, and improved quantification robustness — particularly for semi‑volatile, polar, or structurally heterogeneous analytes that can be challenging for CAD.

Advanced Optical & Electronic Architecture

The SEDEX 100LT integrates a suite of high‑precision components to deliver best‑in‑class analytical performance:

• High‑efficiency photodiode delivering exceptionally wide dynamic range
• Stabilized thermal and optical environment ensuring reproducible scattering signals
• Refined nebulizer compatibility for HPLC, UHPLC and SFC conditions
• Low electronic noise enabling trace‑level impurity profiling

The result is a detector capable of producing stable baselines, crisp peak shapes, and excellent repeatability even under challenging chromatographic conditions.

Intelligent Automation with SAGA Dynamic Gain Control

The SEDEX 100LT incorporates SAGA (SEDEX Automated Gain Adjustment) — an intelligent system that automatically manages detector gain in real time. It enables:

• Continuous optimization of sensitivity
• Protection against overloads and off‑scale peaks
• A much wider usable dynamic range
• Simultaneous detection of main peaks and low‑level impurities

This automation eliminates manual gain adjustments and simplifies both routine and method‑development workflows.

Seamless Integration with Any LC or SFC Platform

The SEDEX 100LT offers maximum flexibility and system compatibility:

Front‑panel operation or full PC‑based control

Wide portfolio of drivers supporting major CDS platforms
(Chromeleon, OpenLab, ChemStation, Xcalibur, and others)

Remote automatic shutdown, switching off gas, heater, photodiode and light source at end of run
→ reduces gas consumption and extends instrument lifetime

SOP documentation included for GLP compliance and fast validation

Key Advantages of the SEDEX 100LT

✔ True Low‑Temperature Evaporation

Ensures maximum sensitivity and preserves fragile analytes.

✔ Universal Detection

Captures virtually any analyte without chromophores or ionization requirements.

✔ Sensitivity Comparable or Superior to CAD

Direct optical detection provides robust performance across varied analyte classes.

✔ High‑Precision Optics & Electronics

Delivers outstanding baseline stability and reproducible quantification.

✔ Broad Software Integration

Compatible with leading chromatography data systems.

✔ SAGA Dynamic Gain Control

Automated sensitivity optimization for all workflows.

✔ GLP‑Ready Documentation

Complete SOP package included.

Key Advantages of the SEDEX 100LT

The SEDEX 100LT is ideally suited for:

✔ High‑Sensitivity Quantitative Analysis

Trace impurities, low‑level degradants, and challenging matrices requiring ultra‑low noise and strong S/N.

✔ Stability & Stress‑Testing Studies

Excellent for thermolabile or semi‑volatile compounds sensitive to high temperatures or ion‑based detection.

✔ Complex Mixture Profiling

Universal detection for samples containing a wide diversity of chemical structures — lipids, carbohydrates, surfactants, polymers, peptides, natural products, excipients.

✔ Pharmaceutical R&D and QC

Consistency, robustness and GLP‑friendly features make it ideal for validated analytical methods and regulated workflows.

✔ UHPLC & SFC High‑Resolution Separations

Fast separations benefit from the SEDEX 100LT’s rapid optical response and wide dynamic range.

✔ When UV, RI or MS Fall Short

Perfect for analytes lacking chromophores, poorly ionizable species, or compounds incompatible with MSD source conditions.